Prostacyclin, High Densit Lipoproteins, and Myocardial Ischemia
نویسنده
چکیده
E ver since the discovery of prostacyclin (originally termed PGX by Moncada et all but later designated PGI2, there has been considerable interest in its role in cardiovascular homeostasis. Despite the fact that PGI is not cleared by the lung in contrast to virtually all other prostaglandins, its circulating concentration is very low.23 This low circulating PG12 level is in part due to its instability in aqueous media at physiological pH, its rapid rate of metabolism, and its uptake by target tissues. The half-life of prostacyclin in blood is generally acknowledged to be about 3 minutes.4 Despite its short half-life, prostacyclin has been accorded a prominent role in vascular homeostasis because it has potent biological effects that act as a defensive humoral agent opposing the untoward effects of thromboxane A2 (TXA2). In this connection, 10 nM prostacyclin can totally block the marked degree of platelet
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